Guided Enamel Regeneration
Guided Enamel Regeneration (GER) is a regenerative treatment of initial carious lesions. GER bridges the gap between prevention and invasive restorative treatments. It enables effective therapy of initial caries through in-depth regeneration of the enamel, whilst still maintaining the integrity of the tooth. By diffusing rapidly until the depth of early, active, non-cavitated early carious lesions (Caries classification table for indications of Curodont Repair) and forming new hydroxyapatite crystals, the Monomer-Peptide 104 technology in Curodont Repair enables Guided Enamel Regeneration via an easy, non-invasive and pain-free application.
Mode of Action
The technology in CurodontTM Repair is formulated as a low viscosity liquid with high affinity to hydroxyapatite. The unique conditions within carious lesions enable the organization of the peptide monomers into the biomatrix. This matrix guides the regeneration of enamel by serving as a ‘platform’ for the formation of new hydroxyapatite crystals.
Carious lesion with a pseudo-intact enamel surface layer
The Monomer-Peptide 104 technology diffuses until the depth of the carious lesion within 5 minutes
The peptides of the Monomer-Peptide104 technology assemble into a biomatrix within the carious lesion
The biomatrix formed by the Monomer-Peptide104 technology attracts calcium and phosphate ions from the saliva for de novo nucleation of hydroxyapatite crystals, leading to remineralization
Scientific & Clinical Evidence
Curodont Repair (CR) demonstrates significantly superior Inactivation and Regression of Early Caries compared to Fluoride Varnish (FV) alone.1
After 6 months, 80% of caries treated with CR+FV became inactive as opposed to only 34% of those treated with FV alone, as assessed by Nyvad Caries Activity Criteria.
Greater decrease in laser fluorescence readings (assessed using DIAGNODent), signifying greater caries regression for treatment with CR+FV compared to FV alone.
